Importance of the Adrenergic Nerve System in the Response of Gases in the Arterial Blood Following the Provoked Bronchospasm - Zdravlje, medicina, lijecenje, zdravstveni portal

Importance of the Adrenergic Nerve System in the Response of Gases in the Arterial Blood Following the Provoked Bronchospasm

Importance of the Adrenergic Nerve System in the Response of Gases in the Arterial Blood Following the Provoked Bronchospasm

Hilmi Islami, Arta Veseli, Emir Behluli, Naim Morina

Med Arh. 2012; 66(5): 292-295

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Abstract

Introduction: this work, partial pressure of the respiratory gases in the capillary blood (pH, PaO2, PaCO2) was studied, following the protective action of the beta2-adrenergic stimulator-Hexoprenaline and alpha2-adrenergic blocker-Tolazoline in the bronchoconstriction caused by a beta-blocker-Propranolol. Material and methods: in patients with increased bronchial reactibility. pH, oxygen partial pressure (PaO2), dioxide carbon partial pressure (PaCO2) in the arterial blood, with the assistance of the analyzer IL, following some minutes of sample taking were defined in all patients. As a standard to verify the accuracy of the measurement, ampoule solutions of pH, PaO2 and PaCO2 were utilized (Acidobasel, Berlin). Results and discussion: Following the inhalation of the beta-blocker-Propranolol (20 mg/ml–aerosol), there was an evident decrease (p<0.05) of pO2 and a non-significant increase (p>0.1) of pCO2. Beta2-adrenergcic stimulator–Hexoprenaline (2 inh x 0.2 mg), shows an protective effect in the decrease of pO2 (p<0.05) following the bronchoconstriction being provoked by Propranolol. Alpha2-adrenergic blocker-Tolazoline (20 mg/ml-aerosol), has not shown a protective action in the bronchoconstriction caused with propranolol, therefore significant decrease (p<0.05) of pO2 and a non-significant increase (p> 0.1) of pCO2 appeared. This shows that stimulation of beta2-adrenergic receptor has protective action in changes of the respiratory gases. Meantime, blocker of the alpha2-adrenergic receptor (Tolazoline) has not shown a protective action in changes of the respiratory gases.

REFERENCES

1. Pedly TJ, Schroter RC, Sudlok MF. The predication of pressure drop and variation of resistence within the human bronchial airways. Resp Physiol. 1970; 9: 387.

2. Wichert P Von. Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders. CT.S. Karger Publishers. Formington, 1994.

3. Islami HI. Receptorët adrenergjikë dhe rrugët ajrore. P Medica. 38: 13-19.

4. Szentivanyi A. The beta adenergic theory of atopic abnormality in bronchial asthma. J Allergy. 1968; 42-203.

5. Barnes PJ. Mechanisms of Disease: Airway receptors. Postgraduate Medical Journal. 1989; 65: 532-542.

6. Rosenthal RR, Kondarskky DW, Rosenberg GL, Norman PS. The role of alpha-adrenergic receptors in allergic asthma. J Allerg Clin Immunol. 1976; 57: 223.

7. Dergacheva O, Griffion KJ, Neff RA, Mendelowitz D. Respiratory modulation of premotor cardiac vagal neurons in the brainstem. Respir Physiol Neurobiol. 2010; (1-2): 102-110.

8. Kamburoff PL, Prime FJ. Thymoxamine and airway obstruction. Lancet. 1974; 1: 1288.

9. Gross GN, Souhrada FJ, Farr RS. The long-term treatment of asthmatic patients using phentolamine. Chest. 1974; 66: 397.

10. Black J, Temple D, Anderson SD. Long-term trial of an alpha adrenoceptor blocking drug (indoramine) in asthma. Scand J Dis. 1978; 59: 307.

11. Pratter MR, Irwin RS. The clinical value of pharmacologic bronchoprovocation challenge. Chest. 1984; 85: 260-265.

12. Subcommittee on Bronchial Inhalation Chellenges, Assembly of Allergy and Clinical Immunology, ATS News. Spring. 1980; 11-19.

13. Wagner PD, Dantzker DR, Iacovoni VE, Tomlin WC. Ventilation-perfusion inequality in asymptomatic asthma. Am Rev Respir Dis. 1978; 118: 511-524.

14. Weitzman RH, Wilson AF. Diffusing capacity and overall ventilation: perfusion in asthma. Am J Med. 1974; 57: 767-574.

15. Burke TV, Kung M, and Burki NK. Pulmonary gas exchange during histamine-induced bronchoconstriction in asthmatic subjects. Chest. 1989; 96: 752-756.

16. Haxhiu MA. Rano otkrivanje oboljenja malih disajnih puteva. U: Bolest malih disajnih puteva, Prishtina, 1976.

17. Braunwald “Hypoxia and Cyanosis”, Harrison’s Principles of Internal Medicine 15th edition. McGraw-Hill, 2001: 214-216.

18. Breen W. “Arterial Blood Gas and pH Analysis”, Anesthesiol Clin N Amer. 2001 19(4):

19. Comroe JH. Physiology of Respiration ed.2. Chicago, Year Book, Medical Publicters, 1974.

20. Burke TV, Kűng M, Burki NK. Pulmonary gas exchange during histamine-induced bronchoconstriction in asthmatic subjects. Chest. 1989; 96: 752-756.

21. Petrini MF, Robertson HT, Hlastala MP. Interaction of series and parallel dead space in the lung. Respire Physiol. 1983; 54: 121-136.

22. Hlastala MP. Multiple inert gas elimination technique. J Apppl Physiol. 1984; 56: 1-7.

23. Freyschuss U, Hedlin G, Hedenstierna G. Ventilation-perfusion relationship during exercise-induced asthma in children. Am Rev Respir Dis. 1984; 130: 888-894.

24. Poppius H, Stenius B. Changes in arterial oxygen saturation in patients with hyperreactive airways during a histamine inhalation test. Scand J respire Dis. 1977; 58: 1-4.

25. Ballester E, Roca J, Rodrigues-Roisin R, Augusti-Vidal A. Effect of nifedipine on arterial hypoxemia occurring after methacholine challenge in asthma. Thoraz. 1986; 41: 468-472.

26. Felez MA, Roca J, Barbera JA, Santos C, Rotger M, Chung KF, and Rodriguez-Roisin R. Inhaled platelet-activating factor worsens gas exchange in mild asthma. Am J Respir Crit Care Med. 1994; 150: 369-373.

27. Lagerstrand L, Larsson K, Ihre E, Zetterstrom O, and Hedenstierna G. Pulmonary gas exchange response following allergen challenge in patients with allergic asthma. Eur Respir J. 1992; 5: 1176-1183.

28. Echazarreta AL, Dahlen B, Garcia G, Agusti C, Barbera JA, Roca J, Dahlen SE, Rodriguez-Roisin R. Pulmonary gas exchange and sputum cellular responses to inhaled leukotriene D4 in asthma. Am J Respir Crit Care Med. 2000; 1164: 202-206.

29. Echazarreta AL, Gomez FP, Ribas J, Sala E, Barbera JA, Roca J, Rodriguez-Roisin R. Pulmonary gas exchange responses to histamine and methacholine challenges in mild asthma. Eur Respir J. 2001; 17: 609-614.

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