Stress as Provoking Factor for the First and Repeated Multiple Sclerosis Seizures - Zdravlje, medicina, lijecenje, zdravstveni portal

Stress as Provoking Factor for the First and Repeated Multiple Sclerosis Seizures

Stress as Provoking Factor for the First and Repeated Multiple Sclerosis Seizures
Jasminka Djelilovic-Vranic, Azra Alajbegovic, Merita Tiric-Campara, Amina Nakicevic, Eldina Osmanagic, Senka Salcic, Majda Niksic
Mat Soc Med. 2012; 24(3): 142-147

View PDF Fulltext


Introduction: Paracetamol is one of the most used antipyretic- analgesic preparation, which can be found in different pharmaceutical forms and in different doses. Due to its wide utilization in the clinical practice, determination of paracetamol in pharmaceutical formulation is of a great importance since that over dosage with paracetamol may cause the hepatic fulminant necroses and other toxic effects. Material and methods: Study has included two formulations of paracetamol suppositories with doses of 125 mg widely used in the paediatric practice. Suppositories prepared according to these two formulations by the melting method and spilling into forms was subject to the quality control by implementing a series of trials and analyses for that aim, such are: reactions of identification, average mass, disintegration time, and homogeneity whilst quantitative determination was performed by applying two methods of instrumental analyze: spectrophotometry in UV zone and cromatography in liquid phase with high pressure. Results and discussion: Results of these analyses, performed immediately following the preparation and 3 months after the preparation, showed that content of paracetamol in both of two formulations is within the norms of Pharmacopoeia. Suppositories of paracetamol in doses of 125 mg prepared as per formulation 1 are to be considered as more appropriate because it contains semi synthetic glycerides as excipient which has better features than other suppository excipients.


1. COPE Code of Conduct and Best Practice Guidelines for Journal Editors.

2. Wager E. Coping with misconduct. BMJ 2011;343:d6586 (also available at

3. Sox HC, Rennie D. Research misconduct, retraction, and cleansing the medical literature. Lessons from the Poehlman case. Ann Intern Med. 2006; 144: 609-613.

4. Wager E, Kleinert S. On behalf of COPE Council. Cooperation between research institutions and journals on reseach integrity cases: guidance from the Committee on Publication Ethics (COPE). and published in this issue.

5. Närvänen T, Lipsanen T, Antikainen O, Räikkönen H, Yliruusi J. Controlling granule size by granulation liquid feed pulsing. Int J Pharm, 2008; 357: 132–138.

6. Rantanen J, Rasanen E, Tenhunen J, Kansakoski M, Mannermaa JP, Yliruusi J. In-line moisture measurement during granulation with a four-wavelength near infrared sensor: an evaluation of particle size and binder effects. Eur J Pharm. Biopharm, 2000; 50: 271–276.

7. British Pharmacopoeia, Paracetamol, Stationery Office, London. UK, 2004.

8. European Pharmacopoeia 6th ed., Paracetamol, EDQM, Strasbourg. France, 2007.

9. The United States Pharmacopoeial Convention, United States Pharmacopoeia 30. Acetaminophen tablets, The United States Pharmacopoeial Convention, Rockville. USA, 2006.

10. Visavarugnroj N, Remon JP. Crossed link starch as disintegrating agent granulation in higher mixewr. Int J Pharm. 1992; 92: 125-131.

11. British Pharmacopoeia. Appendix XII D: Dissolution test for tablets, capsules and supositas. London: British Pharmacopoeia Commission, 2004.

12. British Pharmacopoeia. Specific monograph: paracetamol. London: British Pharmacopoeia Commission, 2004.

13. British Pharmacopoeia. General monograph: supositas. London: British Pharmacopoeia Commission, 2004.

14. Haywood A, Mangan M, Glass B. Stability Implications of Repackaging Paracetamol Tablets, supp. into Dose Administration Aids. Journal of Pharmacy Practice and Research, 2006; 36: 53-61.

Leave a reply

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>